New Drug R&D

New Drug R&D

As assay technologies continue to improve, biophysical techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), surface plasmon resonance (SPR), and isothermal titration calorimetry (ITC) have become a key component of drug discovery platforms for many pharmaceutical companies and laboratories. Biophysical methods are widely used for hit discovery (fragment-based screening and high-throughput screening), hit validation, in-depth characterization of compound binding, and lead compound optimization.

CD BioSciences is committed to providing researchers with comprehensive, sensitive, and professional biophysical analysis services to advance early characterization of compounds and drug discovery by incorporating relationships between kinetics, molecular structure, and interactions.

New Drug R and D

Surface Plasmon Resonance (SPR)

SPR can monitor the whole process of interaction between various biomolecules such as peptides, proteins, oligonucleotides, oligosaccharides, lipids, and even whole viruses and cells in real time by sensor chip without using fluorescence or isotope labeling or even purification of various biocomponents under natural conditions. SPR has a wide range of applications in life sciences, medical testing, drug screening, food testing, environmental monitoring, and other fields.

X-ray crystallography

X-ray crystallography is a commonly used method to analyze protein structure. By exposing protein crystals to X-ray beams and determining the X-ray diffraction patterns, the atomic level structure of proteins can be deduced. Currently, X-ray crystallography plays an important role in structure-based drug design (SBDD), where accurate analysis of the crystal structures of target macromolecules and macromolecule-ligand complexes is essential at all stages.

Nuclear Magnetic Resonance (NMR)

NMR is a technique for detecting the resonant frequencies of proteins and small molecules in a magnetic field. NMR provides near-atomic resolution of dynamic processes in proteins on a nanosecond to millisecond time scale. These dynamic processes are the basis for the metastable effects of proteins and elucidate their thermodynamic and kinetic properties. Therefore, NMR has become the method of choice for the development of metathesis inhibitors. In addition, NMR can be used in drug discovery to identify, characterize, and validate new impurities, degradants, as well as metabolites in raw materials, active pharmaceutical ingredients, formulated products, or biological samples for studies such as structural determination of compounds, analysis of their content, and identification of impurities.

Isothermal Titration Calorimetry (ITC)

ITC is an important method to study bio-thermodynamics and bio-kinetics, which continuously and accurately monitors and records the calorimetric curve of a changing process by a highly sensitive and automated microcalorimeter, providing thermodynamic and kinetic information simultaneously in situ, online, and non-destructively. It is of great significance in the study of protein-protein interactions, protein-sugar interactions, drug-protein interactions, interactions between small molecules and proteins, and kinetic analysis of enzymatic reactions.

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CD BioSciences is equipped with an advanced biophysical technology platform, including NMR spectroscopy, X-ray crystallography, ITC, SPR, and other biophysical techniques. Our comprehensive technology can provide researchers with an array of biophysical analysis services related to drug discovery. If you are interested in our services, please contact us.

For research use only, not intended for any clinical use.
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CD BioSciences is a biotechnology company focused on biophysical services. We are proficient in both chemistry and biophysics, and have a comprehensive biophysical platform containing a wide range of advanced technologies.

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