As assay technologies continue to improve, biophysical techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), surface plasmon resonance (SPR), and isothermal titration calorimetry (ITC) have become a key component of drug discovery platforms for many pharmaceutical companies and laboratories. Biophysical methods are widely used for hit discovery (fragment-based screening and high-throughput screening), hit validation, in-depth characterization of compound binding, and lead compound optimization.
CD BioSciences is committed to providing researchers with comprehensive, sensitive, and professional biophysical analysis services to advance early characterization of compounds and drug discovery by incorporating relationships between kinetics, molecular structure, and interactions.
Applications in Drug R&D
CD BioSciences' biophysical analysis service team has rich practical experience and professional knowledge and can provide personalized analysis solutions for different needs of drug development. We are committed to providing customers with efficient, accurate, and reliable biophysical analysis services and promoting innovation and progress in drug R&D.
Drug-Target Molecule Interaction Studies
We offer X-ray crystallography techniques to determine the spatial structure and conformational information between drugs and target molecules, and to reveal the mechanism of their interaction. By exposing protein crystals to X-ray beams and determining X-ray diffraction patterns, the atomic level structure of a protein can be deduced. Currently, our X-ray crystallography analysis service is widely used in structure-based drug design (SBDD) and drug-target molecule interaction studies.
Drug Screening
We provide nuclear magnetic resonance (NMR) technology for drug discovery to identify, characterize, and validate active pharmaceutical ingredients for compound structure determination, analysis, and other studies of their content and identification of impurities. Our isothermal titration calorimetry (ITC) technology evaluates the strength and duration of drug-biomolecule interactions to aid in the drug screening and optimization process.
Pharmaceutical Analysis
Our service platform provides a variety of spectroscopic analysis techniques such as fluorescence, infrared, and nuclear magnetic resonance spectroscopy for structural, purity, and content determination of drugs to ensure their quality and stability. In addition, mass spectrometry with high sensitivity and resolution provides the basis for precise structural identification of drug molecules and analysis of trace components.
Advantages of Our Services
- High efficiency. Our professional biophysical platform can quickly analyze the structure and composition of drugs, accelerate the screening and optimization process, and further provide new directions for new drug development.
- High sensitivity. Our biophysical analysis technology can accurately determine the spatial structure and conformational information of drug molecules to further understand the properties of drug molecules and provide accurate guidance for drug design.
- Innovative. We integrate the cutting-edge technologies of physics and biology to provide an all-round biophysical platform and innovative strategies for drug discovery and development, thus promoting the progress of drug discovery and development.
Related Services
CD BioSciences is equipped with an advanced biophysical technology platform, including NMR spectroscopy, X-ray crystallography, ITC, SPR, and other biophysical techniques. Our comprehensive technology can provide researchers with an array of biophysical analysis services related to drug discovery. If you are interested in our services, please
contact us.
For research use only, not
intended for any clinical use.
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