Drug delivery in vivo is often affected by physiological and pathological barriers, including hepatic metabolism, renal filtration, immune clearance, and various tissue barriers. In addition, the in vivo application of traditional chemical drugs is often limited by low solubility, short retention time, unsatisfactory bioavailability, and poor targeting ability. Advanced drug delivery systems can give drugs new prescriptions and routes of administration, helping to extend the life cycle of drugs and the inventor's monopoly over the product. Therefore, designing drug delivery systems that can efficiently load drugs and deliver them to the target site has become a major challenge in drug research.
CD BioSciences offers a wide range and depth of biophysical services for drug delivery applications to enhance drug solubility and bioavailability further, prolong retention time, as well as enhance target delivery and cellular uptake while minimizing side effects.
Carrier Design
In recent years, nanoparticle-based drug delivery has significantly progressed in disease treatment. Nanomaterials have excellent biodegradability and biocompatibility which are considered as the best carriers for drug delivery systems in biomedical applications. Biophysical techniques can help to design more effective drug delivery carriers that contain exosomes, liposomes, or microemulsions in addition to nanoparticles. These carriers not only have good biocompatibility and stability but also can realize targeted delivery and controlled release of drugs. Lately, researchers have developed nanoparticles encapsulating ribonucleic acid (RNA) in vaccines widely used in medicine.
Study of Mechanisms
Biophysical services can reveal the microscopic mechanisms of drug delivery and transportation, such as the interaction of drug molecules with biological structures like cell membranes and organelles, as well as the distribution and metabolism of drugs in the body. This information helps researchers to understand the mechanism of drug action more deeply and provides theoretical support for optimizing drug transport. In addition, specialized simulation techniques can predict and evaluate the relevant mechanisms of drugs in the transport process, further revealing the solubility, stability, and permeability of drugs.
Safety Assessment
Delivery systems can induce biological signaling and soluble factor delivery, thereby regulating cell behavior and function. The safety of drug delivery systems is assessed by biophysical techniques, such as detecting the toxicity, immunogenicity, or effects of nanodrug carriers on other biomolecules in vivo. These results can help better understand the potential risks of drug delivery systems and develop appropriate safety strategies.
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CD BioSciences, a leader in biophysical analysis, focuses on developing and refining advanced technologies, services, and solutions that make significant contributions to the development of drug delivery systems in the biopharmaceutical field. If you would like more information, please contact us.
For research use only, not
intended for any clinical use.
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