Synaptic transmission is an extremely complex phenomenon. CD BioSciences focuses on the development of novel techniques to help clients analyze synaptic transmission and plasticity, providing new insights into the conventional interpretation of synaptic function. Our efficient technical services will greatly accelerate your progress in neuroscience research.
Our brains receive and process information from the outside world all the time, and the information is passed between neurons in the nervous system via synapses. Since synaptic inputs always increase, eliminate and refine in response to ongoing neural activity, the efficacy and weight of synapses in the brain are highly variable. And this plasticity represents the brain's ability to change and adapt to new information.
Methods from multiple fields such as electrophysiology and molecular biology have been applied to synaptic neuroscience research. A variety of experimental techniques have been developed to assess synaptic plasticity, such as single-cell electrophysiological recordings. Recent technological developments allow the combination of optical tools with classical electrophysiological methods, providing neuroscientists with innovative and promising tools to study synaptic transmission.
Fig.1 Sample long-term potentiation (LTP) and depression (LTD) experiments show presynaptic expression. (Brock, 2020)
We offer our clients services for synaptic transmission and plasticity analysis by combining electrophysiological techniques with optical techniques. In addition, we offer genetically encoded optical reporters and actuators to add cell type specificity to this analysis. As the interpretation of electrophysiological data depends on many parameters, such as ionic flux and voltage dependence, we use multiple experimental techniques to evaluate all possible sites of action. Our services include but are not limited to:
CD BioSciences has developed a variety of advanced techniques to provide our clients with professional and comprehensive services in the field of synaptic neuroscience. If you are interested in our services, please feel free to contact us.
CD BioSciences is a biotechnology company focused on biophysical services. We are proficient in both chemistry and biophysics, and have a comprehensive biophysical platform containing a wide range of advanced technologies.