Drug screening is a step in the modern drug development process to test and obtain compounds with specific physiological activity, selecting compounds with higher activity for a specific target of action from many compounds or new compounds through standardized biophysical techniques. With the development of modern medicine and biology, drug-directed screening has been gradually applied. At the same time, with the continuous improvement of detection technology, the throughput of drug screening is also continuously improved.
CD BioSciences has established biophysical platforms, including surface plasmon resonance (SPR), microscale thermophoresis (MST), and isothermal titration calorimetry (ITC) for early-stage drug screening, which promotes the drug development process.
High Throughput Screening
High throughput screening is possible through the use of biophysical techniques such as surface plasmon resonance (SPR), microscale thermophoresis (MST), and isothermal titration calorimetry (ITC). In addition, technicians can evaluate many drug candidates simultaneously, allowing for rapid screening of promising compounds. Biophysical technologies can greatly reduce the time to find new drugs and improve the efficiency of drug screening.
Enhanced Screening Efficiency
The detection object of SPR is not limited to interactions between macromolecules, but can also realize the detection of protein-small molecule and nucleic acid-small molecule interactions. Since SPR technology can directly reflect the strength and kinetic pattern of the interaction between two molecules, the SPR method can be used to screen protein compound libraries and small molecule compound libraries, which greatly reduces the false positive rate and significantly improves the efficiency of drug screening. Biophysical technology can quickly and accurately assess the interaction between drugs and target proteins, thus helping researchers to quickly screen potential compounds from a large number of drug candidates.
Drug-target Interaction Analysis
Biophysical techniques can provide kinetic, thermodynamic, and structural information on drug-target interactions. This detailed information helps researchers gain a deeper understanding of the drug's mechanism of action, leading to more effective drug optimization and design.
Target Protein Detection
Biophysical techniques include SPR, MST, nanoDSF, BLI, DLS, etc. These methods can accurately control and analyze the quality, function, binding strength, and other parameters of target proteins. This is crucial for determining drug-target interactions and helps screen for more effective and safer drug candidates.
Guidance of New Drug Development Direction
Through in-depth research on the biophysical properties of drug candidates, researchers can obtain important references and bases on the direction of new drug development, which will help pharmaceutical companies formulate more effective R&D strategies, reduce R&D costs, and improve the success rate of new drug development.
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CD BioSciences, as an expert in the field of biophysics, strives to develop and refine advanced technologies and services that make a critical contribution to drug screening in new drug discovery and development. If you would like more information, please contact us at any time.
For research use only, not
intended for any clinical use.
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