CD BioSciences is committed to developing techniques for biomolecular interaction analysis to help our customers assess affinity during drug development. We offer microscale thermophoresis (MST) technology to determine binding affinity (KD), stoichiometry and other aspects of interactions, so as to accelerate the progress of customers in drug development.
MST is an emerging technique for the analysis of biomolecular interactions developed based on the thermophoretic effect. The technique measures the affinity between a ligand and a target molecule by observing changes in the conformational size, charge and solvation state of the target molecule after the ligand has bound to it. Elucidating the kinetic, thermodynamic and chemical principles of affinity correlation is very important for high-throughput screening in the early stage of new drug development.
MST has been widely used as a powerful biophysical method in drug discovery studies to analyze and quantify biomolecular interactions. We use the unique properties of MST to rapidly generate binding data for our clients with high accuracy and informative content, while minimizing time and sample consumption. Moreover, the technology has the characteristics of no fixed sample, low sample consumption and easy operation. These advantages make MST a low-risk technology that can be easily integrated into existing workflows.
Fig.1 MST setup and experiments. (Jerabek-Willemsen, 2014)
We provide our clients with MST measurements to analyze and quantify biomolecular interactions. The services we provide include but are not limited to:
Combining the expertise of MST with our advanced biophysical analysis platform, we are confident that we can offer our clients a wide range of services at different stages of drug discovery.
CD BioSciences has built a superior MST platform to provide binding affinity measurement services to our customers. Our specialist biophysical analysis services will provide you with vital data for your research in the field of drug discovery. If you are interested in our services, please contact us for more details.
CD BioSciences is a biotechnology company focused on biophysical services. We are proficient in both chemistry and biophysics, and have a comprehensive biophysical platform containing a wide range of advanced technologies.