CD BioSciences is committed to building a professional and integrated biophysical technology platform to provide efficient scientific services and technical support to our clients in membrane biophysics research. We apply the techniques and concepts of physics to help our clients study the composition, structure, the relationship between physical properties and function of bio-membranes, providing vital information for membrane research.

Introduction

The cell membrane not only acts as the boundary membrane of the cell to provide a relatively stable internal environment for cellular activities, but also plays important roles in the transport of substances, energy conversion, information transfer and cellular recognition between the cell and the environment. An in-depth study of the cell membrane structure is the basis for understanding the mysteries of cellular life activities. In recent years, along with the advancement of various biophysical techniques, the study of biological membranes and membrane proteins has made rapid progress.

The field of membrane biophysics aims to elucidate the laws governing the movement of matter, energy and information in organisms within a given space and time. A variety of biophysical analysis techniques have been applied to the study of membranes. These include the structure, function and regulation of channels and transport proteins, ligand and receptor interactions, and protein trafficking and secretory mechanisms. In contrast to membrane biology, membrane biophysics focuses more on quantitative information and modeling of various membrane phenomena. The study of membrane biophysics will help to further promote the application of membranes in many fields such as agriculture, medicine and industry.

Fig.1 SEC-MALS analysis of the membrane protein. (Kwan, 2019)

Our Services

Our state-of-the-art technology platform provides a wide range of biophysical analysis tools for our clients to study membranes. we offer services including but not limited to:

• Structure analysis of cell membranes.
• AFM-Based Biophysical Analysis of Membranes (High-resolution imaging, morphological and structural analysis, etc.)
• Detection of membrane mechanical properties and endocytosis.
• Super-resolution imaging of membrane heterogeneity.
• Single-molecule fluorescence analysis of living cell membranes.
• Electron microscopic analysis of the plasma membrane and cell surface molecules.
• Characterization of membrane proteins.
• Infrared spectrum analysis of plasma membranes.
• Computer simulations to explore membrane organization and transport.

Our Technologies

The techniques we provide include but are not limited to:

• In situ dynamic light scattering (DLS)
• Size-exclusion chromatography multi-angle light scattering (SEC-MALS)
• Circular dichroism (CD)/Synchrotron radiation circular dichroism (SRCD)
• Differential scanning fluorimetry (DSF) assay
• Mid-infrared spectroscopy (MIR)
• Lipidic cubic phase fluorescence recovery after photobleaching (LCP-FRAP)
• Single-molecule force spectroscopy
• Synchrotron X-ray diffraction

CD BioSciences has established a comprehensive and advanced biophysical analysis platform and can provide expert technical support to accelerate our clients' projects in the field of membrane research. With our extensive expertise in membrane biophysics, we can provide you with the best combination of technologies and experimental solutions. Please feel free to contact us for more details.

Reference

1. Kwan, T. O. C.; et al. Selection of biophysical methods for characterisation of membrane proteins. International Journal of Molecular Sciences. 2019, 20(10): 2605.

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