Biophysical Measurement of Red Blood Cells

Biophysical Measurement of Red Blood Cells

Biophysical Measurement of Red Blood Cells

CD BioSciences is committed to developing a variety of innovative spectroscopic and microscopic methods to help clients determine multiple biophysical parameters of red blood cells (RBCs) at the molecular level. Our expert scientific services will accelerate your overall understanding of RBCs morphology and function, thereby optimizing the detection and diagnosis of RBC-related diseases.

Background

The physical properties (mechanical and electrical properties) of RBCs have been intensively studied over the last decade because of their physiological and pathological importance. It is well known that the exceptional deformability of RBCs is closely related to both the macrocirculation and the microcirculation. Impaired deformability of RBCs leads to a variety of diseases such as sepsis, malaria, sickle cell anemia (hemoglobin disorder), and microvascular dysfunction. In addition, the electrical properties of RBCs are also associated with pathological conditions.

Advances in biophysical measurements have made it possible to use label-free, less invasive methods to characterize RBCs and to study unknown structure-function relationships. A number of techniques have been used to measure the biophysical properties of RBCs, such as atomic force microscopy and optical tweezers. However, these techniques are difficult to use and the speed of testing is low. Currently, the application of modern spectroscopic, microscopic and microfluidic techniques to biomedical analysis is opening up new horizons and providing new perspectives in the study of RBCs and the pathology of RBC-related diseases.

Fig.1 Microfluidic system for electrical and mechanical characterization of red blood cells. (Zheng, 2012)Fig.1 Microfluidic system for electrical and mechanical characterization of red blood cells. (Zheng, 2012)

Our Services

Our researchers are committed to developing a wide range of modern spectroscopic, microfluidic and microscopic-based techniques to assist our clients in the determination of multiple biophysical parameters of RBCs. Our services include but are not limited to:

  • Assessment of the number, morphology, structural alterations, and enzymatic activity of RBCs.
  • Characterization of membrane viscoelastic properties and stiffness of RBCs.
  • Characterization of the electrical properties of RBCs.
  • Analysis of RBC surface antigen expression.
  • Analysis of the structure of hemozoin.
  • Determination of biophysical properties of RBC membranes.
  • Detection of the blood components present in low concentrations.
  • Monitoring dynamic processes in blood in real-time.
  • Detection of samples containing Hb degradation or heme metabolites.
  • Distinction between RBCs and RBCs in malaria infection.
  • Multiparametric biophysical analysis of RBCs in malaria infection, including density, magnetic susceptibility, and morphological characteristics.

Our Technologies

  • Flow cytometry
  • Raman spectroscopy (RS)
  • Fourier-transform infrared spectroscopy (FT-IR)
  • Electron paramagnetic resonance
  • M√∂ssbauer spectroscopy
  • Atomic force microscopy
  • Scanning electron microscopy
  • Scanning near-field optical microscopy

CD BioSciences is committed to providing comprehensive scientific services for our clients' biomedical research, including detailed RBCs biophysical characterization services. Our professional research team will provide the best experimental scheme, which includes one or more analytical methods, according to your research direction and expected results. If you are interested in our services, please contact us for more details.

Reference

  1. Zheng, Y.; et al. High-throughput biophysical measurement of human red blood cells. Lab on a Chip. 2012, 12(14): 2560-2567.
For research use only, not intended for any clinical use.
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CD BioSciences is a biotechnology company focused on biophysical services. We are proficient in both chemistry and biophysics, and have a comprehensive biophysical platform containing a wide range of advanced technologies.

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