Biomedical science increasingly recognizes the importance of biophysics in health and disease. Researchers often combine theories and methods from multiple disciplines, such as medicine, physics, chemistry, structural biology and engineering, to address scientific questions in biomedical research. In recent years, rapid technological developments in the field of biophysics, such as spectroscopy, electrophysiology and various imaging techniques have provided powerful tools to study the structural morphology, physiological features, metabolic functions and pathological characteristics of biological tissues, accelerating the development of research and applications in the biomedical field.

With a team of researchers with in-depth knowledge of physics and biology, CD BioSciences offers a wide range of specialist biophysical analysis services to help clients investigate scientific problems in biomedical research. We are committed to developing new techniques and methods that can be used to study the structure and function of macromolecules, organelles and cells, as well as experimental and computational methods for understanding biomedicine. In short, our innovative biophysical analysis techniques and bioinformatics tools provide important technical support for our clients' advances in basic medicine, further providing useful information for the diagnosis, treatment and prevention of disease.

Fig.1 Applications for Raman spectroscopy in biomedicine. (Brauchle, 2013)

Our Services

• Impedance Measurements for Biomedical Research
  We provide our clients with impedance measurement services from whole-body analysis to single cell and cellular monolayers, providing vital information for gaining insight into human physiological and pathological processes.
• Mechanical Characterization of Biological Cells
  We help clients quantify the global and local mechanical properties of living cells to study the perception, conversion and response of cells to mechanical signals.
• Analysis of Iron-Containing Biomolecules
  We are dedicated to developing the application of Mössbauer spectroscopy in biomedicine research and helping clients analyze iron-containing biomolecules under the influence of pathological processes or environmental factors.
• Biophysical Measurement of Red Blood Cells
  We have developed a wide range of modern spectroscopic, microfluidic and microscopic-based techniques to assist our clients in the determination of multiple biophysical parameters of red blood cells.
• Characterization of Heart Mitochondria
  We help our clients characterize the biophysical characteristics of heart mitochondria for a wide range of animal models.
• Detection of Insulin and Glucagon
  We provide our clients with non-destructive and label-free characterization for islets of Langerhans, including the detection of insulin and glucagon and the identification of different cell types in pancreatic cell lines by Raman microspectroscopy.
• Evaluation of Biophysical Properties of Bone Tissue
  We provide clients with services to assess the biophysical properties of bone tissue, including the detection of parameters for evaluating bone quality and the analysis of mechanical properties.
• Detection and Identification of Neoplastic Cells
  We help clients identify neoplastic cells and normal cells as well as detect and quantify tumor biomarkers.
• Characterization of Bionanomaterials
  We provide clients with structural characterization services of bionanomaterials used for biomedical and biotechnology to determine the physicochemical properties of nanomaterials.
• Monitoring of Drug Release
  We offer our clients drug release monitoring services through non-invasive imaging technologies, providing accurate, real-time and in-situ information on drug release to elucidate the mechanisms of cellular uptake and guide the design of new drugs.
• Development of Tumor-Targeted Contrast Agent
  We are dedicated to the development and application of tumor-targeted contrast agents in medical imaging to enhance the ability to characterize specific disease phenotypes.
• In Vivo Imaging Services for Biomedical Research
  We provide in vivo imaging services based on bioluminescence and fluorescence technologies to perform measurements from the cellular level to the organ level and the animal level.
• Development of Optical Biosensors for Infectious Disease Diagnosis
  We are committed to helping our clients develop a variety of optical biosensors to provide rapid and reliable results for the identification and quantification of disease-causing virus particles in samples.
• High-Resolution Imaging and Characterization of Various Biomolecules
  Based on our AFM technology platform, we provide high-resolution imaging and characterization services for various biomolecules (including cells, organelles, proteins, DNA, biofilms, and bacteria) in biomedical research, helping our clients to understand the details of morphological structures, mechanical properties, and interactions of biological samples to advance the development of biomedical research.

As a biotechnology company with technological innovation at its core, CD BioSciences' long-term goal is to develop advanced biophysical techniques and data analysis methods to help our clients investigate scientific questions in the biomedical field. If you are interested in our biophysical analysis services, please contact us for more details.

Reference

1. Brauchle, E.; Schenke-Layland, K. Raman spectroscopy in biomedicine: non-invasive in vitro analysis of cells and extracellular matrix components in tissues. Biotechnology journal. 2013, 8(3): 288-297.

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