Neurotransmitter Release Research
The structure of the brain and its functions have always been an important target of research in the process of human self-awareness, while the study of the molecular mechanisms of transmission and release of neurotransmitters has been a top priority. Recent studies have revealed that neurotransmitter release is influenced by key marker protein molecules in neurodegenerative diseases. Currently, more and more studies are utilizing advanced single-molecule biophysical techniques to detect neurotransmitter release, which can help to understand further the mechanisms of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and thus guide their clinical prevention and treatment.
CD BioSciences, with its well-established single-molecule biophysical technologies and rich experience, provides specialized services to lay the foundation for studying neurocognitive functions and the mechanisms of neurodegenerative diseases.
Fluorescence Energy Resonance Transfer (FRET)
In the active region of the presynaptic membrane, synaptic vesicles carrying neurotransmitters need to undergo four important processes: tethering, anchoring, maturation, and membrane fusion, each of which involves the synergistic action of important proteins, phospholipids, and their related complexes. Currently, artificial vesicle reconfiguration based on fluorescence energy resonance transfer (FRET) has been widely used in the study of synaptic protein-mediated membrane fusion mechanisms in vitro. FRET is an effective method for the qualitative and quantitative detection of interactions between biological macromolecules. By labeling pairs of FRET molecules on artificial vesicles, FRET changes caused by membrane fusion can be observed to study the membrane fusion mechanism.
In addition, FRET can also observe the spatial distribution between proteins and proteins, proteins and phospholipid molecules, protein complexes and biological membranes at a given moment, as well as their real-time interactions and dynamic structural changes, which will greatly advance the study of the molecular mechanisms of the brain's nervous system.
Related Services
CD BioSciences is committed to providing professional technical support and biophysical analysis services to researchers in the field of neuroscience. We focus on research on neurotransmitter release to help explore the pathogenesis of neurodegenerative diseases. If you are interested in our services, please feel free to contact us.
For research use only, not
intended for any clinical use.
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